Impact of hypertension with or without diabetes on left ventricular remodeling in rural Chinese population: a cross-sectional study

نویسندگان

  • Tan Li
  • Shuang Chen
  • Xiaofan Guo
  • Jun Yang
  • Yingxian Sun
چکیده

BACKGROUND The aim of this study was to assess the impact of hypertension with or without diabetes on left ventricular (LV) remodeling in rural Chinese population. METHODS A total of 10,270 participants were classified into control group, hypertension without diabetes (HT) group, and hypertension with diabetes (HT + DM) group. We compared clinical characteristics and echocardiographic parameters, and used multivariable logistic regression analysis to assess the associations of interest. RESULTS HT + DM group had higher interventricular septal thickness (IVSd), posterior wall thickness (PWTd), left ventricular mass (LVM), LVM index (LVMI), relative wall thickness (RWT), left atrial diameter (LAD), A wave and lower E wave than HT group (all P < 0.05). The prevalence rates of left ventricular hypertrophy (LVH) and abnormal geometry were statistically different among three groups (P < 0.001) and eccentric hypertrophy was the highest proportion of geometry abnormality. Logistic regression analysis suggested that subjects in HT and HT + DM groups had odds ratio (OR) values of 2.81, 4.41, 2.24 and 3.94, 7.20, 2.38 for LVH, concentric hypertrophy and eccentric hypertrophy in the total population, respectively, compared to control group. When compared with HT group, those in HT + DM group had approximately 1.40-, 1.61- and 1.38-, 1.71-fold increased risk for LVH and concentric hypertrophy in the total and female population separately, but no association of HT + DM with LVH and abnormal geometrical patterns was found in men. CONCLUSIONS This study demonstrated that, to varying degrees, hypertension was associated with LV remodeling in rural Chinese population, and this risk association was obviously increased for LVH and concentric hypertrophy when accompanied by diabetes, especially for women.

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Author’s response to reviews Title: Impact of Hypertension with or without Diabetes on Left Ventricular Remodeling in Rural Chinese Population: a Cross-Sectional Study Authors:

Thank you for your letter and we were very pleased that the academic editor requested us to make minor revisions. We also thank the reviewers for his/her constructive suggestions. These suggestions improve the rigor of our design of this study and help us a lot. We have made correction which we hope meet with approval. Revised portion have been marked in red in the revised manuscript. The main ...

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عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2017